Shanghai Longyao Biotechnology Co., Ltd. was established in 2013 and is located in Jing'an District, Shanghai. It is committed to tumor immune cell technology and product research and development, product technology transformation, and product registration application. It is a national high-tech enterprise focusing on research and development and product development. Products cover hematological tumors, solid tumors and other fields.
Longyao Biological Development History:
China Biotechnology Services Holdings Co., Ltd. is a listed company on the Growth Enterprise Market of the Stock Exchange: code 8037.HK, referred to as "China Biotechnology Services", and was included in the Hong Kong MSCI Micro Cap Index in May 2018; the layout " Precision Diagnosis : Accurate Big Health Testing System " ” and “ Precision Therapy : Cell Therapy Integrated Industry Chain”.
At present, 12 tumor immune cell product pipelines have been deployed. At this stage, two new CAR-T cell products (CD19 UCAR-T and CD20 CAR-T-OX40, First-in-class/Best-in-class) are registered Reporting is the focus and core of development.
Core product pipeline:
1. Longyao universal UCART: the world's first echelon, unique TCR knockout technology
CD19UCAR-T, CD20 UCAR-T and CD20 CAR-T-OX40 have carried out exploratory clinical trials and are expected to apply for clinical trials in 2H19-1H20.
2. Longyao CD20-CAR-T-OX40: a new generation of CART structure of systematic optimization platform
Original expression of new costimulatory factor technology: stronger proliferation and anti-tumor activity, while the expression of PD-1, LAG-3 and other immune checkpoints is reduced, and the immune suppression of the tumor microenvironment is relieved.
The core product pipelines CD19 UCAR-T, CD20 CAR-T-OX40 and CD20 UCAR-T have applied for PCT and Chinese patents, and the patent of X CAR-T is pending.
3. Longyao DC1-CTL technology: type 1 polarized DC vaccine treatment technology from the University of Pittsburgh, USA
Longyao Bio has currently developed antigen peptide kits for 15 types of tumors.
4. Longyao Biotechnology LY004: Enhancing tumor recruitment of CAR-T cells
LY004 can chemotactic to tumor cells, enhance T cell recruitment in tumor tissues, and can have a significant synergistic effect with CAR-T against solid tumors.
Shanghai Longyao Biotechnology takes biotechnology and products as technology promotion and improvement of human health as its own responsibility. Now it has established clinical research cooperation and technology promotion of tumor immune technology with a number of domestic university hospitals, provincial hospitals and military hospitals. A professional company dedicated to the clinical promotion of biotechnology has signed a technology entrustment promotion agreement; Shanghai Longyao Bio provides the hospital with overall scientific research and technical solutions: start clinical research together with the hospital, help the hospital to establish a cytology laboratory and achieve technical success , Jointly carry out the clinical academic promotion of biotherapeutic technology.
Company philosophy:
Based on the corporate philosophy of "rigorous, innovative, caring, and service", Shanghai Longyao Biotechnology makes unremitting efforts for the benefit of human health through biotechnology.
Rigor - Rigorously cultivate the details
A career in human health requires a rigorous work attitude. Technology is precious for rigorous refinement, and work is precious for rigorous pursuit of progress. It is necessary to be vigorous and resolute at the same time. Forge a rigorous style, create a rigorous atmosphere, and create a rigorous team.
Creativity - innovation strives for breakthroughs
Innovation is the driving force behind the world's scientific development. We attach great importance to the accumulation and learning of past experiences, and more emphasis on past breakthroughs and progress. Institutional innovation, technological innovation, concept innovation, and innovation in all places that require innovation are our persistent core competitiveness.
Care - Caring for people
Caring is a human virtue. Patients need care, employees need care, our career requires us to be full of love for all work, harmony begins with care, and care starts from bit by bit.
Service - Service creates the future
We serve human health. Facing patients, we provide professional and attentive services; facing partners, we provide win-win cooperation and mutually beneficial services; facing colleagues, we support and care for each other. Service is our responsibility and our mission.